Inhibiting SIRP-α & CD47 Interaction Can Prevent T-Cell Mediated Transplant Allograft Rejection

A new discovery from Pitt, in collaboration with the University of Toronto, was published in Friday in the journal Science Immunology that outlines how inactivating dendritic cells ultimately prevents T-Cell mediated rejection of donor allografts. This has profound implications on transplant rejection.

The model is based off the premise that SIRP-α, a marker protein on donor allograft binds to the CD47 receptor on recipient monocytes, inducing them to become dendritic cells which in turn create recipient T cells that attack the donor allograft. Inhibiting this interaction can prevent the attack on the donor allograft, thereby inhibiting rejection without depleting T cells. The video provides this in diagram.

Senior author, Fadi Lakkis, MD scientific director of the Thomas E. Starzl Transplantation Institute at the University of Pittsburgh wants to confirm this by,

“…sequenc(ing) the SIRP-α gene in many humans who are donors and recipients of organ or bone marrow, and then ask whether a mismatch affects the outcome after transplantation.”